20 settembre 2008

Pillola della settimana. Arcoxia come il Vioxx?


Tutti gli antinfiammatori sono uguali?
Sembrerebbe proprio di no. Basti pensare al Vioxx e alla Nimesulide.

Il nuovo antinfiammatorio che ora desta molte perplessità è Etoricoxib, il quale risulterebbe potenzialmente pericoloso come il Vioxx.

Un Panel della Food and Drug Administration, l'ente americano che controlla e gestisce i farmaci, ha votato 20 a 1 contro l’approvazione di Arcoxia (Etoricoxib), un farmaco antinfiammatorio di Merck & Co.

Arcoxia, secondo gli esperti dell’Agenzia Federale sui Farmaci sarebbe associato a rischio cardiovascolare, come l’altro antinfiammatorio Cox-2, Vioxx (Rofecoxib), ritirato dal mercato nel 2004.

L’FDA, su indicazioni del Panel degli Esperti, ha respinto la domanda di immissione in commercio presentata dalla società produttrice di Arcoxia, Merck & Co.



Gli studi hanno trovato che Arcoxia aumenta di quasi 3 volte il rischio di infarto miocardico, ictus e di mortalità rispetto al Naprossene (Synflex, Naprosyn).

Secondo Robert Shibuya, dell’FDA, su 1 milione di persone che passano dal Diclofenac (Voltaren) ad Arcoxia, 2300 soggetti potrebbero andare incontro a infarto miocardico, ictus o morte.

Etoricoxib è stato invece approvato dall’EMEA ed è venduto in Italia con i nomi commerciali di Arcoxia, Algix, Tauxib.

Come mai lo stesso farmaco viene proibito negli Stati Uniti e commercializzato in Europa?
Fate molta attenzione ai farmaci che vi prescrivono, informatevi sempre nel modo che credete più opportuno prima di iniziare una cura farmacologica.
Passo.




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